A simplified function-first method for the discovery and optimization of bispecific immune engaging antibodies.

Bi-specific T-cell engager antibodies (BiTEs) are synthetic fusion molecules that combine multiple antibody-binding domains to induce active contact between T-cells and antigen expressing cells in the body.Blinatumomab, a CD19-CD3 BiTE is now a widely used therapy for relapsed B-cell malignancies, and similar BiTE therapeutics have shown promise fo

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AHP6 inhibits cytokinin signaling to regulate the orientation of pericycle cell division during lateral root initiation.

In Arabidopsis thaliana, lateral roots (LRs) initiate from anticlinal cell divisions of pericycle founder cells.The formation of LR primordia stickers logos dallas cowboys is regulated antagonistically by the phytohormones cytokinin and auxin.It has previously been shown that cytokinin has an inhibitory effect on the patterning events occurring dur

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Incidence and factors associated with agitation in patients on mechanical ventilators in Amhara Region, North-West Ethiopia: a multi-center study

Abstract Agitation is a common psychomotor disorder among critically ill patients on mechanical ventilators, posing significant risks to patients and adding strain to clinical services.Despite its importance, there is a lack of data on the incidence and contributing factors of agitation in the study area and across Ethiopia.This study, therefore, a

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Reactivation/Acceleration of Landslides Caused by the 2018 Baige Landslide-Dammed Lake and its Breach Floods Revealed by InSAR and Optical Images

here Landslide-dammed lakes and their breaches can reactivate/accelerate landslides, causing potential damages.However, in the absence of displacement observations, the spatial-temporal deformation patterns of the landslide-dammed lakes and associated floods reactivated/accelerated landslides remain underexplored.In this article, we u

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